Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development
نویسندگان
چکیده
منابع مشابه
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
Diacylglycerol (DAG) is an important lipid signalling molecule that exerts an effect on various effector proteins including protein kinase C. A main mechanism for DAG removal is to convert it to phosphatidic acid (PA) by DAG kinases (DGKs). However, it is not well understood how DGKs are targeted to specific subcellular sites and tightly regulates DAG levels. The neuronal synapse is a prominent...
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Karam Kim, Jinhee Yang, Xiao-Ping Zhong, Myoung-Hwan Kim, Yun Sook Kim, Hyun Woo Lee, Seungnam Han, Jeonghoon Choi, Kihoon Han, Jinsoo Seo, Stephen M Prescott, Matthew K Topham, Yong Chul Bae, Gary Koretzky, Se-Young Choi and Eunjoon Kim* National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAI...
متن کاملS-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95
PSD-95, a principal scaffolding component of the postsynaptic density, is targeted to synapses by palmitoylation, where it couples NMDA receptor stimulation to production of nitric oxide (NO) by neuronal nitric oxide synthase (nNOS). Here, we show that PSD-95 is physiologically S-nitrosylated. We identify cysteines 3 and 5, which are palmitoylated, as sites of nitrosylation, suggesting a compet...
متن کاملCDKL5 variants
Objective: To provide new insights into the interpretation of genetic variants in a rare neurologic disorder, CDKL5 deficiency, in the contexts of population sequencing data and an updated characterization of the CDKL5 gene. Methods: We analyzed all known potentially pathogenic CDKL5 variants by combining data from large-scale population sequencing studies withCDKL5 variants from new and all av...
متن کاملPreso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.
PSD-95 is an abundant postsynaptic density (PSD) protein involved in the formation and regulation of excitatory synapses and dendritic spines, but the underlying mechanisms are not comprehensively understood. Here we report a novel PSD-95-interacting protein Preso that regulates spine morphogenesis. Preso is mainly expressed in the brain and contains WW (domain with two conserved Trp residues),...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1300003110